Dr. Ishaq N. Khan

Dr. Ishaq has joined department of Pharmacology, Institute of Basic Medical Sciences
Khyber Medical University in January 2017 and currently working as Assistant Professor in department of
Molecular Biology & Genetics. In year 2017, he has established a “cancer tissue culture facility” and
developed a research group (Pakistan NeuroOncology Research Group – PK-NORG) in collaboration with
renowned neurosurgeons from different hospitals including Northwest General Hospital, Hayatabad
Medical Complex and Lady Reading Hospital. Previously he has worked in international “Transitional
NeuroOncology Group” where he has generated primary brain cancer cells from Arabian patients.
Dr. Ishaq’s primary area of doctorate research was focused on the characterization of drug
resistant cells in primary brain tumors, where he has studied the molecular analysis of pathogenesis,
pleomorphism, apoptosis, cancer stem cells presence and unique genetic signatures of meningiomas, that
resulted in discovery of AGR2 as a novel marker for aggressive meningiomas. The work has been
presented at different platforms including at “Neurooncology 20th scientific meeting” in San Antonio, TX,
USA and at DKFZ (German cancer research center) in Hiedelberg, Germany. Currently at IBMS, KMU he
has generated primary cells from wide range of adult and paediatric brain tumors’ patients including
meningiomas, medulloblastomas, pituitary tumors, schwannomas, glioblastomas and other astrocytic
tumors. His main focus is to investigate different biological and molecular aspects of CNS tumors that will
majorly cover the genomic, proteomic and metabolomic instabilities in Pakistani population, with ultimate
aim of novel drug discovery and improved therapeutic outcome.
Dr. Ishaq has 16 research publications to his credit in impact journals. He is currently
supervising/co-supervising 12 M.Phil. and 3 Ph.D. Students. He has recently completed a project on brain
tumors under a start-up research grant that was awarded by Higher Education Commission of Pakistan.
 

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